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The human body is the entire structure of a . It is composed of many different types of cells that together create tissues and subsequently organs and then .

The external human body consists of a , , , (which includes the and ), , , , , and . The internal human body includes organs, , , , , , and , and .

The study of the human body includes , , and . The body varies anatomically in known ways. Physiology focuses on the systems and organs of the human body and their functions. Many systems and mechanisms interact in order to maintain , with safe levels of substances such as , , and in the blood.

The body is studied by health professionals, physiologists, anatomists, and artists to assist them in their work.


Composition
Elements of the human body by mass. are less than 1% combined (and each less than 0.1%). ElementSymbolPercent massPercent atoms
OxygenO65.024.0
CarbonC18.512.0
HydrogenH9.562.0
NitrogenN3.21.1
CalciumCa1.50.22
PhosphorusP1.00.22
PotassiumK0.40.03
SulfurS0.30.038
SodiumNa0.20.037
ChlorineCl0.20.024
MagnesiumMg0.10.015
Trace elements < 0.1< 0.3

The human body is composed of including , , , and . These elements reside in trillions of cells and non-cellular components of the body.

The adult male body is about 60% content of some . This is made up of about of extracellular fluid including about of and about of interstitial fluid, and about of fluid inside cells. The content, acidity and composition of the water inside and outside cells is carefully maintained. The main in body water outside cells are and , whereas within cells it is and other .


Cells
The body contains trillions of cells, the fundamental unit of life. At maturity, there are roughly 30 trillion cells, and 38 trillion bacteria in the body, an estimate arrived at by totaling the cell numbers of all the organs of the body and cell types. The skin of the body is also host to billions of commensal organisms as well as immune cells. Not all parts of the body are made from cells. Cells sit in an extracellular matrix that consists of such as , surrounded by extracellular fluids.

Each of the cells of the human body experiences, on average, tens of thousands of DNA damages per day. These damages can block replication or genome transcription, and if they are not or are repaired incorrectly, they may lead to , or other genome alterations that threaten cell viability.


Genome
Cells in the body function because of . DNA sits within the . Here, parts of DNA are copied and sent to the body of the cell via . The RNA is then used to create , which form the basis for cells, their activity, and their products. Proteins dictate cell function and gene expression, a cell is able to self-regulate by the amount of proteins produced. However, not all cells have DNA; some cells such as mature red blood cells lose their nucleus as they mature.


Tissues
The body consists of many different types of tissue, defined as cells that act with a specialised function. The study of tissues is called and is often done with a . The body consists of four main types of tissues. These are lining cells (), connective tissue, and .


Cells
Cells that line surfaces exposed to the outside world or gastrointestinal tract () or internal cavities () come in numerous shapes and forms – from , to cells with small beating hair-like in the lungs, to column-like cells that line the . Endothelial cells are cells that line internal cavities including blood vessels and glands. Lining cells regulate what can and cannot pass through them, protect internal structures, and function as sensory surfaces.


Organs
Organs, structured collections of cells with a specific function, mostly sit within the body, with the exception of . Examples include the , and . Many organs reside within within the body. These cavities include the abdomen (which contains the stomach, for example) and , which contains the lungs.


Heart
The heart is an organ located in the between the and slightly to the left. It is surrounded by the , which holds it in place in the and serves to protect it from blunt trauma, and help lubricate the movement of the heart via pericardial fluid. The heart works by pumping blood around the body allowing , , , and white blood cells to be transported. The heart is composed of two atria and two ventricles. The primary purpose of the atria is to allow uninterrupted venous blood flow to the heart during . This allows enough blood to get into the ventricles during . Consequently, the atria allows a roughly 75% greater than would be possible without them. The purpose of the ventricles is to pump blood to the lungs through the right ventricle and to the rest of the body through the left ventricle.

The heart has an electrical conduction system to control the contraction and relaxation of the muscles. It starts in the traveling through the atria causing them to . It then travels to the atrioventricular node, which makes the signal slow down slightly allowing the ventricles to fill with blood before pumping it out and starting the cycle over again.

Coronary artery disease is the leading cause of death worldwide, making up 16% of all deaths. It is caused by the buildup of in the coronary arteries supplying the heart, eventually the arteries may become so narrow that is able to reach the , a condition known as myocardial infarction or heart attack, this can cause or and eventually death. Risk factors for coronary artery disease include obesity, smoking, high cholesterol, , lack of exercise and . , though it is exceedingly rare and has usually from another part of the body such as the or . This is because the quickly stop dividing and all growth occurs through rather than .


Gallbladder
The gallbladder is a hollow pear-shaped organ located posterior to the inferior middle part of the right lobe of the liver. It is variable in shape and size. It stores before it is released into the small intestine via the common bile duct to help with . It receives bile from the via the , which connects to the common hepatic duct to form the common bile duct.

The gallbladder gets its blood supply from the , which in most people, emerges from the right hepatic artery.

is a common disease in which one or more stones form in the gallbladder or . Most people are asymptomatic but if a stone blocks the biliary tract, it causes a ; symptoms may include sudden pain in the upper right abdomen or center of the abdomen. Nausea and vomiting may also occur. Typical treatment is removal of the gallbladder through a procedure called a . Having gallstones is a risk factor for gallbladder cancer, which, although quite uncommon, is rapidly fatal if not diagnosed early.


Systems

Circulatory system
The circulatory system consists of the and (, and ). The heart propels the circulation of the blood, which serves as a "transportation system" to transfer , fuel, nutrients, waste products, immune cells and signaling molecules (i.e. ) from one part of the body to another. Paths of blood circulation within the human body can be divided into two circuits: the pulmonary circuit, which pumps blood to the lungs to receive and leave , and the systemic circuit, which carries blood from the heart off to the rest of the body. The blood consists of fluid that carries cells in the circulation, including some that move from tissue to blood vessels and back, as well as the and .
(1993). 9780139811760, Pearson Prentice Hall. .


Digestive system
The digestive system consists of the mouth including the and , , , (gastrointestinal tract, and , and ), as well as the , , , and . It converts food into small, nutritional, non-toxic for distribution and absorption into the body. These molecules take the form of (which are broken down into ), , and minerals (the last of which are mainly ionic rather than molecular). After being , food moves through the gastrointestinal tract by means of : the systematic expansion and contraction of muscles to push food from one area to the next.

Digestion begins in the , which food into smaller pieces for easier digestion. Then it is , and moves through the to the . In the stomach, food is mixed with to allow the extraction of . What is left is called ; this then moves into the , which absorbs the nutrients and water from the chyme. What remains passes on to the , where it is dried to form ; these are then stored in the until they are expelled through the .


Endocrine system
The consists of the principal : the , , , , parathyroids, and , but nearly all organs and tissues produce specific endocrine as well. The endocrine hormones serve as signals from one body system to another regarding an enormous array of conditions, resulting in variety of changes of function.


Immune system
The consists of the white blood cells, the , and channels, which are also part of the . The immune system provides a mechanism for the body to distinguish its own cells and tissues from outside cells and substances and to neutralize or destroy the latter by using specialized proteins such as , , and toll-like receptors, among many others.


Integumentary system
The integumentary system consists of the covering of the body (the ), including hair and nails as well as other functionally important structures such as the and . The skin provides containment, structure, and protection for other organs, and serves as a major sensory interface with the outside world.
(2025). 9780805359107, Pearson Benjamin Cummings. .


Lymphatic system
The extracts, transports and metabolizes lymph, the fluid found in between cells. The lymphatic system is similar to the circulatory system in terms of both its structure and its most basic function, to carry a body fluid.


Musculoskeletal system
The musculoskeletal system consists of the (which includes , , , and ) and attached . It gives the body basic structure and the ability for movement. In addition to their structural role, the larger bones in the body contain , the site of production of blood cells. Also, all bones are major storage sites for calcium and . This system can be split up into the and the .
(2025). 9781605476520, Lippincott Williams & Wilkins.


Nervous system
The consists of the body's and cells, which together form the , and , which in turn form the and related structures. The brain is the organ of , emotion, , and sensory processing; it serves many aspects of communication and controls various systems and functions. The consist of vision, , , and smell. The , , , and gather information about the body's environment.

From a structural perspective, the is typically subdivided into two component parts: the central nervous system (CNS), composed of the brain and the ; and the peripheral nervous system (PNS), composed of the nerves and outside the brain and spinal cord. The CNS is mostly responsible for organizing , processing , thought, memory, and other such functions. It remains a matter of some debate whether the CNS directly gives rise to . The peripheral nervous system (PNS) is mostly responsible for gathering information with and directing body movements with .

From a functional perspective, the nervous system is again typically divided into two component parts: the somatic nervous system (SNS) and the autonomic nervous system (ANS). The SNS is involved in voluntary functions like and . The ANS is involved in involuntary processes, such as and regulating .

The nervous system is subject to many different diseases. In , abnormal electrical activity in the brain can cause . In multiple sclerosis, the attacks the , damaging the nerves' ability to transmit signals. (ALS), also known as 's disease, is a disease which gradually reduces movement in patients. There are also many other diseases of the nervous system.


Reproductive system
The purpose of the reproductive system is to reproduce and nurture the growth of offspring. The functions include the production of germ cells and hormones. The of the male reproductive system and the female reproductive system develops and mature at . These systems include the internal and external .

Female puberty generally occurs between the ages of 9 and 13 and is characterized by and ; the growth of secondary sex characteristics, such as growth of and , , and growth, widening hips and increased height and weight, also occur during puberty. Male puberty sees the further development of the and .

The female inner sex organs are the two ovaries, their , the , and the . At birth there are about 70,000 that degenerate until at puberty there are around 40,000. No more egg cells are produced. Hormones stimulate the beginning of menstruation, and the ongoing . The female external sex organs are the (, , and ).

The male external genitalia include the penis and that contains the . The testicles are that produce the which are in through the penis. Unlike the egg cells in the female, sperm cells are produced throughout life. Other internal sex organs are the , , and some accessory glands.

Diseases that affect the reproductive system include polycystic ovary syndrome, a number of disorders of the testicles including testicular torsion, and a number of sexually transmitted infections including , , , HPV and . can affect most parts of the reproductive system including , testicles, , , , , fallopian, and .


Respiratory system
The respiratory system consists of the nose, , , and . It brings oxygen from the air and excretes and water back into the air. First, air is pulled through the trachea into the lungs by the diaphragm pushing down, which creates a . Air is briefly stored inside small sacs known as alveoli (sing.: alveolus) before being expelled from the lungs when the diaphragm contracts again. Each alveolus is surrounded by carrying deoxygenated blood, which absorbs oxygen out of the air and into the bloodstream.
(2025). 9780134234359, .

For the respiratory system to function properly, there need to be as few impediments as possible to the movement of air within the lungs. of the lungs and excess are common sources of breathing difficulties. In , the respiratory system is persistently inflamed, causing or shortness of breath. occurs through of the alveoli, and may be caused by . Emphysema, commonly a result of , is caused by damage to connections between the alveoli.


Urinary system
The consists of the two , two , , and . It removes waste materials from the blood through urine, which carries a variety of waste molecules and excess and water out of the body.

First, the filter the blood through their respective , removing like , and maintaining the proper balance of and turning the waste products into by combining them with water from the blood. The kidneys filter about 150 quarts (170 liters) of blood daily, but most of it is returned to the blood stream with only 1-2 quarts (1-2 liters) ending up as urine, which passes from the kidneys through the into the .

The lining the ureter walls continuously tighten and relax through a process called , forcing small amounts of urine into the bladder every 10–15 seconds.

The bladder is a hollow balloon shaped organ located in the . It stores urine until the brain signals it to relax the urinary sphincter and release the urine into the urethra starting . A normal bladder can hold up to 16 ounces (half a liter) for 3–5 hours comfortably.

Numerous including kidney stones, which are formed when materials in the urine concentrate enough to form a solid mass, urinary tract infections, which are infections of the urinary tract and can cause pain when urinating, frequent urination and even death if left untreated. occurs when the kidneys fail to adequately filter waste from the blood and can lead to death if not treated with or kidney transplantation. can affect the , , and , with the latter two being far more rare.


Anatomy
Human is the study of the shape and form of the human body. The human body has four limbs (two arms and two legs), a head and a , which connect to the . The body's shape is determined by a strong made of and , surrounded by fat (), muscle, connective tissue, organs, and other structures. The at the back of the skeleton contains the flexible , which surrounds the , which is a collection of nerve fibres connecting the to the rest of the body. connect the spinal cord and brain to the rest of the body. All major bones, muscles, and nerves in the body are named, with the exception of anatomical variations such as and .

Blood vessels carry blood throughout the body, which moves because of the beating of the . and collect blood low in oxygen from tissues throughout the body. These collect in progressively larger veins until they reach the body's two largest veins, the superior and inferior vena cava, which drain blood into the right side of the heart. From here, the blood is pumped into the where it receives oxygen and drains back into the left side of the heart. From here, it is pumped into the body's largest , the , and then progressively smaller arteries and until it reaches tissue. Here, blood passes from small arteries into , then small veins and the process begins again. Blood carries , waste products, and from one place in the body to another. Blood is filtered at the and .

The body consists of a number of , separated areas which house different organ systems. The brain and central nervous system reside in an area protected from the rest of the body by the blood brain barrier. The lungs sit in the . The intestines, , and sit in the .

Height, weight, and other vary individually and with age and sex. Body shape is influenced by the distribution of bones, and .


Physiology
Human is the study of how the human body functions. This includes the mechanical, physical, bioelectrical, and functions of humans in good health, from organs to the cells of which they are composed. The human body consists of many interacting systems of organs. These interact to maintain , keeping the body in a stable state with safe levels of substances such as sugar and oxygen in the blood.

Each system contributes to homeostasis, of itself, other systems, and the entire body. Some combined systems are referred to by joint names. For example, the nervous system and the endocrine system operate together as the neuroendocrine system. The nervous system receives information from the body, and transmits this to the brain via and . At the same time, the releases hormones, such as to help regulate and volume. Together, these systems regulate the internal environment of the body, maintaining blood flow, posture, energy supply, temperature, and acid balance (pH).


Development
Development of the human body is the process of growth to maturity. The process begins with fertilisation, where an egg released from the of a female is penetrated by . The egg then lodges in the , where an and later develop until . Growth and development occur after birth, and include both physical and psychological development, influenced by genetic, hormonal, environmental and other factors. Development and growth continue throughout life, through , , and through to , and are referred to as the process of .


Society and culture

Professional study
Health professionals learn about the human body from illustrations, models, and demonstrations. Medical and dental students in addition gain practical experience, for example by of cadavers. Human anatomy, , and are basic medical sciences, generally taught to medical students in their first year at medical school.
(2025). 9780443071683, Elsevier Churchill Livingstone. .
(2025). 9780443071683, Elsevier Churchill Livingstone. .


Depiction
In Western societies, the contexts for depictions of the human body include , and . Information includes both science and education, such as anatomical drawings. Any ambiguous image not easily fitting into one of these categories may be misinterpreted, leading to disputes. The most contentious disputes are between fine art and erotic images, which define the legal distinction of which images are permitted or prohibited.


History of anatomy
In , the Hippocratic Corpus described the anatomy of the skeleton and muscles. The 2nd century physician compiled classical knowledge of anatomy into a text that was used throughout the Middle Ages. In the , (1514–1564) pioneered the modern study of human anatomy by dissection, writing the influential book De humani corporis fabrica. Anatomy advanced further with the invention of the and the study of the cellular structure of tissues and organs. Modern anatomy uses techniques such as magnetic resonance imaging, , and ultrasound imaging to study the body in unprecedented detail.


History of physiology
The study of human physiology began with in Ancient Greece, around 420 BCE, and with (384–322 BCE) who applied critical thinking and emphasis on the relationship between structure and function. () was the first to use experiments to probe the body's functions. The term physiology was introduced by the French physician (1497–1558). In the 17th century, (1578–1657) described the circulatory system, pioneering the combination of close observation with careful experiment. In the 19th century, physiological knowledge began to accumulate at a rapid rate with the of Matthias Schleiden and in 1838, that organisms are made up of cells. (1813–1878) created the concept of the milieu interieur (internal environment), which Walter Cannon (1871–1945) later said was regulated to a steady state in . In the 20th century, the physiologists Knut Schmidt-Nielsen and George Bartholomew extended their studies to comparative physiology and .
(1987). 9780521349383, Cambridge University Press.
Most recently, evolutionary physiology has become a distinct subdiscipline.


See also


Human body lists
  • List of skeletal muscles of the human body
  • List of organs of the human body
  • List of distinct cell types in the adult human body
  • List of human microbiota


Books


External links

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